Meine Publikationen

Klein, H (1982) Untersuchungen an isolierten Langerhansschen Inseln zur Rolle der
mi­to­­­chon­dria­len At­mung bei der Auslösung der Insulinsekretion. Dissertation,
Universtät Göttingen (1982)

Panten U, Klein H (1982) O2-consumption by isolated pancreatic islets as measured
in a microin­cu­bation system with a Clark-type electrode. Endocrinology 111: 1595-
1600                                                                                                                                     (4,8)

Klein HH, Freidenberg GR, Cordera R, Olefsky JM (1985) Substrate specificities
 of  insulin and epidermal growth factor receptor ki­nases. Biochem Biophys Res
Comm 127:  254-263                                                                                                           (2,6)

Freidenberg GR, Klein HH, Cordera R, Olefsky JM (1985) Insulin receptor kinase
in rat liver: Regulation by fasting and high car­bo­hydrate fee­ding. J Biol Chem 260:
 12444-12453                                                                                                                       (5,3)

Freidenberg GR, Klein HH, Kladde MP, Cordera R, Olefsky JM (1986) Regu-
lation  of epidermal growth factor receptor number and phospho­rylation by fasting
in rat liver. J Biol Chem 261: 752-757                                                                                 (5,3)

Klein HH, Freidenberg GR, Kladde MP, Olefsky JM (1986) Insulin activation of
insulin receptor kinase in intact rat adipocytes: An in vitro system to measure histone
kinase activity of insulin recep­tors activated in vivo. J Biol Chem. 261: 4691-4697         (5,3)

Freidenberg GR, Henry RR, Klein HH, Reichart DR, Olefsky JM (1987) De-
creased kinase activity of insulin receptors from adipocytes of non-insulin depen­dent
dia­betic (NIDDM) subjects. J Clin Invest 79: 240-250                                                    (15,4)

Klein HH, Ciaraldi TP, Freidenberg GR, Olefsky JM (1987) Adenosine modu-
lates insulin activation of insulin receptor kinase in in­tact rat adi­po­cy­tes.
Endocrinology 120: 2339-2345                                                                                           (4,8)

Klein HH, Freidenberg GR, Matthaei S,Olefsky JM (1987) Insulin receptor ki-
nase following internalization  in isolated rat adi­pocytes. J Biol Chem 262 10557-
10564                                                                                                                                   (5,3)

Brillon DJ, Henry RR, Klein HH, Olefsky JM, Freidenberg G (1988) Functional
 and structural differences in human and rat-derived insulin receptors: Cha­rac­te­riza-
tion of the ß-subunit kinase activity. Endocrinology 123: 1837-184                                  (4.8)

Matthaei S, BeneckeH, Klein HH, Hamann G, Kreymann G, Greten H (1990)
Potential mechanism of insulin resistance in ageing: impaired insulin-stimulated glu­­­-
cose trans­port due to a depletion of the intracellular pool of glucose transpor­ters in
Fischer rat adi­po­cy­tes. J Endocrinology 126: 99-107                                                         (2,9)

Matthaei S, Hamann A, Klein HH, Benecke H, Kreymann G, Flier S, Greten H
(1991) Association of metformin´s effect to increase insulin-stimulated glucose trans­-
port with po­tentiation of  insulin-induced translocation of glucose transporters from
an intra­cel­lu­lar pool to the plasma membrane in rat adipocytes. Diabetes 40: 850-857      (8,6)

Klein HH, Matthaei S, Drenckhan M, Ries W, Scriba PC (1991) The relationship
between insulin binding, insulin-activation of insulin re­cep­tor ty­rosine ki­nase, and
insulin-stimulation of glucose uptake in iso­la­ted rat adi­po­cytes. Biochem J 274:
787-792                                                                                                                                (5,2)

Matthaei S, Hamann A, Klein HH, Benecke H, Kreymann G, Flier S, Greten H
(1992) Evidence that metformin increases insulin-stimulated glucose uptake by po-
ten­tiating insulin-induced translocation of glucose transporters from an intracellular
pool to the cell surface in rat adipocytes. Horm Metab Res  26 ( Suppl): 34-41                 (2,7)

​

Benecke H, Flier J, Rosenthal N, Siddle K, Klein HH, Moller DE (1993) Muscle-
specific expression of the human insulin receptor in transgenic mice. Diabetes 42
206-212                                                                                                                                (8,6)

Klein HH, Kowalewski B, Drenckhan M, Neugebauer S, Matthaei S, Kotzke G
(1993) A  microtiter well assay system to measure insulin-activation of insulin
receptor kinase in intact human mononuclear cells: decreased insulin effect in cells
from pa­tients with NIDDM. Diabetes 42: 883-890                                                             (8,6)

Klein HH, Kowalewski B (1993) A microtiter well assay system to measure the
activity state of insulin receptor ki­nase resul­ting from stimulation of intact human
adipocytes with insulin: Com­parison of the activity state "in vi­vo" and following
subsequent maximal deacti­vation and/or ac­tivation of the same receptors"in vi­tro".           
Exp Clin Endocrinol Diabetes 101: 336-337                                                                      (1,7)

Quentmeier A, Daneschmand H, Klein HH, Probst I (1993) Insulin-mimetic ac-
tions of phorbol-ester in cultured adult rat hepatocytes. Lack of phor­bol ester-elicited
inhibition of the insulin signal. Biochem J 289:  549-555                                                   (5,2)

Quentmaier A,Klein HH, Unthan-Fechner K, Probst I (1993) Attenuation of
insulin actions in primary rat hepatocyte cultures through com­plexa­tion of vi­cinal
thiols by phenylarsine oxide. Biol Chem Hoppe-Seyler 374:  965-971                               (2,6)

Matthaei S, Reibold J-P, Hamann A, HäringHU, Greten H, Klein HH (1993)
In vivo metformin-treatment ameliorates insulin resistance. Evidence for poten­tiation
of insu­lin-induced translocation and increased functional activity of glu­cose trans­por-
ters in obese (fa/fa) Zucker rat adipocytes. Endocrinology 133: 304-31                            (4,8)

Klein HH, Vestergaard H, Kotzke G, Pedersen O (1995) Elevation of serum in-
sulin concentration during euglycemic hyperinsulinemic clamp stu­dies leads to si-
milar activation of insulin receptor kinase in muscle of subjects with and without
NIDDM. Diabetes 44: 1310-1317                                                                                       (8,5)

Kotzke G, SchüttM, Missler U, Moller DE, Fehm HL, Klein HH (1995) Bin-
ding of human, porcine and bovine insulin to insulin receptors from human brain,
muscle and adipocytes, and to expressed recombinant alternatively spli­ced receptor
isoforms. Diabetologia 38: 757-763                                                                                     (6,6)

Matthaei S, Trost B, Hamann A, Kausch C, Benecke H, Greten H, Höppner W,
Klein HH (1995) Effect of in vivo thyroid hormone status on insulin signalling and
GLUT1 and GLUT4 glucose transport systems in rat adipocytes. J Endocrinol 144:
347-357                                                                                                                                (2,9)

Vestergaard H, Klein HH, Hansen T, Müller J, Skovby F, Bjorbak C, Ro-
der M, Pe­der­sen O (1995) Severe insulin resistant diabetes in patients with con-
genital muscle fibre type dispro­portion myopathy. J Clin Invest 95: 1925-1932             (15,4)

Hansen BF, Danielsen G, Dreijer K, Sorensen A, Wiber F, Klein HH, Lun­de-
­mose AG (1996) Sustained signalling from the insulin receptor after stimulation
with insulin ana­logues with in­creased mitogenic potency. Biochem J 315:  271-279        (5,2)

Klein HH, Kowalewski B, Drenckhan M, Fehm HL (1996) Insulin stimulation of
human adipocytes activates the kinase of only a frac­tion of the in­sulin receptors.
Am J Physiol 272: E576-E583                                                                                            (4,4)

Baba T, Drenckhan M, Neugebauer S, Klein H Effect of angiotensin II and brady-
kinin on insulin-stimulated tyrosine kinase activity of the in­sulin receptor.
Diabetologia 41 (1998) 742-743                                                                                          (6,6)

Gebken J, Luders B, Notbohm H, Klein HH, Brinckmann J, Muller PK, Bät-
ge B (1999) Hypergravity stimulates collagen synthesis in human osteoblast-like cells:
evi­dence for the involvement of p44/42 MAP-kinases (ERK 1/2). J Biochem 126:
676-682                                                                                                                                (2,0)

Klein HH, Müller R, Vestergaard H, Pedersen O (1999) Implications of com-
pound heterozygous insulin receptor mutations in congenital muscle fibre type
disproportion myopathy for the receptor kinase activation. Diabetologia 42:
245-249                                                                                                                                (6,6)

Krützfeldt J, Grünweller A, Raasch W, Drenckhan M, Klein HH (1999) Micro­-
­titer well assays for protein tyrosine phosphatase activities directed against phos-
­pho­rylated insulin receptor or insulin receptor substrate-1. Anal Biochem 271: 97-99        (3,3)

Bätge B, Feydt A, Gebken J, Klein H, Notbohm H, Müller PK, Brinckmann J
(2000) Age-related differences in the expression of receptors for TGF-ß in human
osteoblast-like cells in vitro. Exp Clin Endocrinol Diabet 108: 311-315                              (1,7)

Bossenmaier B, Strack V, Stoyanov B, Krützfeldt J, Beck, A, Lehmann R, Kelle-
rer M, Klein HH, Ullrich A, Lammers R, Häring HU (2000) Serine residues 1177/
78/82 of the insulin receptor are required for substrate but not autophos­phorylation.
Diabetes 49 : 889-895                                                                                                            (8,5)

Klein HH, Müller R, Drenckhan M, Schütt M, Bätge B, Fehm HL (2000) Insulin
activation of insulin receptor kinase in erythrocytes is not altered in non-insulin-de­-
pendent diabetes and not influenced by hyperglycemia. J Endocri­nol 166:  275-281         (2,9)

Krützfeldt J,Kausch C, Volk A, Klein HH, Rett K, Häring HU, Stumvoll M
(2000) Insulin signaling and action in cultured skeletal muscle cells from lean, heal-
thy humans with high and low insulin sensitivity. Diabetes 49 992-998                               (8,5)

Krützfeldt J, Raasch W, Klein HH (2000) Ramipril increases the protein level of
skeletal muscle insulin receptor substrate-1 and alters protein tyrosine phosphatase
activity in spontaneously hypertensive rats. N-S Arch Pharmacol 362: 1-6.                       (2,6)

Ludwig M, Klein HH, Diedrich K, Ortmann O (2000)  Serum leptin concentrations
throughout the men­strual cycle. Arch Gynecol Obstet 263: 99-101                                      (0,9)

Strack V, Hennige AM, Krützfeldt J,Bossenmaier B, Klein HH, Kellerer M,
Lammers R, Häring HU (2000) Serine residues 994 and 1023/25 are important for
insulin receptor kinase inhibition by pro­tein kinase C isoforms b2 and q.
Diabetologia 43: 443-449                                                                                                      (6,6)

Schütt M, Drenckhan M, Benecke H, Klein HH (2000) Functional characteristics
of Ser1200-mu­tated insu­lin receptors. Eur J Endocrinol 143: 125-131                               (3,5)

Schütt M, Meier M, Drenckhan M, Meyer S, Aries SP, Klein HH (2000) The
HIV-protease inhibitor indinavir impairs insulin signaling in HepG2 cells.
Diabetologia 43: 1145-1148                                                                                                  (6,6)

Grimmsmann T, Levin K, Meyer M,Beck-Nielsen H, Klein HH (2002) Delays
in insulin signaling towards glucose disposal in human skeletal muscle. J Endocrinol
172:645-651                                                                                                                           (2,9)

Jost P, Fasshauer M, Kahn CR, Benito M, Meyer M, Ott V, Lowell BB, Klein HH,
Klein J (2002) Atypical ß-adrenergic effects on insulin signaling and action in ß3-adrenoreceptor-deficient brown adipocytes. Am J Physiol Endocrinol Metab 283:
E146-53                                                                                                                                  (4,4)

Klein J, Fasshauer M, Klein HH, Benito M, Kahn, CR (2002) Novel adipocyte
lines from brown fat: A model system for the study of differentiation, energy meta-
bolism, and insulin action. Bioessays  24: 382-388                                                                (5,1)

Kraus D, Fasshauer M, Ott V, Jost M, Kahn CR, Klein HH, Klein J (2002)
Leptin secretion and negative autocrine crosstalk with insulin in brown adipocytes.
J Endocrinol 175:185-91.                                                                                                      (2,9)

Klein HH, Ullmann S, Drenckhan M,Unthan-Fechner K,Probst I  (2002)
Influence of dexamethasone on insulin actions: Studies in primary cultures of rat
hepatocytes. J Hepatology 37  432-440                                                                                 (7,8)

Meyer MM, Levin K, Grimmsmann T, Beck-Nielsen H, Klein HH (2002) Insulin
 signaling in skeletal muscle of subjects with or without type 2-diabetes and first de­gree
relatives of patients with the disease. Diabetologia 45: 813-822                                          (6,6)

Meyer MM, Levin K, Grimmsmann T, Perwitz N, Eirich A, Beck-Nielsen H,
Klein HH (2002) Troglitazone treatment increases protein kinase B phosphorylation
in skeletal muscle of normoglycemic subjects at risk for the development of diabetes.
Diabetes 51: 2691-2697                                                                                                         (8,5)

Ott V, Fasshauer M, Dalski A, Klein HH, Klein J (2002) Direct effects of ciliary
neurotrophic factor on brown adipocytes: Evidence for a role in peripheral regulation
of energy homeostasis. J Endocrinol 173: R1-8                                                                   (2,9)

Ott V, Fasshauer M, Dalski A, Meier B, Klein HH, Tschöp M, Klein J (2002)
Direct  peripheral effects of ghrelin include suppression of adiponectin expression.
Horm Metab Res 34:640-5                                                                                                    (2,7)

Schütt M, Meier MM, Jost MM, Klein HH (2003) The HIV protease inhibitor
indinavir impairs glycogen synthesis in HepG2-hepatoma cells but does not affect phos-
photyrosine phosphatase activity against phosphorylated insulin receptor substrate 1.
Exp Clin Endocrinol Diabetes 111:16-20                                                                               (1,7)

Wolfrum S, Dendorfer A, Schütt M, Weidtmann B, Tempel K, Klein HH, Domi-
niak P, Richardt G (2004) Simvastatin acutely reduces myocardial reperfusion injury
in vivo by activating the phosphatidylinositide (PI) 3-Kinase/Akt pathway. J Cardio­-       (2,8)
vasc Pharm 44:348-355

Klein J, Westphal S, Kraus D, Meier B, Perwitz N, Ott V, Fasshauer M, Klein
HH (2004) Metformin inhibits leptin secretion via a mitogen-activated protein (MAP)
kinase signaling pathway in adipocytes. J Endocrinol  183:299-307                                   (2,9)

Schütt M, Zhou J, Meier M, Klein HH (2004) Long-term effects of HIV-protease
 inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. J Endocrinol
183: 445-45                                                                                                                            (2,9)

Bosy-Westphal A, Brabant G, Haas V, Onur S, Paul T, Nutzinger D, Klein H,
Hauer M, Muller MJ (2005) Determinants of plasma adiponectin levels in patients
with anorexia nervosa examined before and after weight gain. Eur J Nutr 355-959           (2,9)

Haas V, Onur S, Paul T, Nutzinger DO, Bosy-Westphal A, Hauer M, Brabant G,
Klein H, Müller MJ (2005) Leptin and body weight regulation in patients with ano-
rexia nervosa before and during weight recovery Am J Clin Nutr 81:889-896                    (6,3)

Jost MM, Jost P, Klein J, Klein HH (2005) ß3-adrenergic agonist CL316, 243
 inhibits insulin signaling but not glucose uptake in primary human adipocytes.
Exp Clin Endocrinol Diabetes 113:418-422                                                                         (1,7)

Onur S, Haas V, Bosy-Westphal A, Hauer M, Paul T, Nutzinger D, Klein H, Mül­-
ler MJ (2005) L-Tri-iodothyronine is a major determinant of resting energy expendi-
ture in underweight patients with anorexia nervosa and during weight gain. Eur J
Endocrinol 152:179-84.                                                                                                         (3,5)

Schneider S, Feilen PJ, Schreckenberger M, Schwanstecher M, Schwanstecher C, Buchholz HG, Thews O, Oberholzer K, Korobeynikov A, Bauman A, Comagic S,
Piel M, Schirrmacher E, Shiue CY, Alavi AA, Bartenstein P, Rosch F, Weber MM,
Klein HH, Schirrmacher R (2005) In vitro and in vivo evaluation of novel glibencla-
mide derivatives as imaging agents for the non-invasive assessment of the pancreatic
islet cell mass in animals and humans. Exp Clin Endocrinol Diabetes 113:388-95              (1,7)

Schneider S, Klein HH (2005) Inosine improves islet xenograft survival in immuno­-
competent diabetic mice. Eur J Med Res 10:283-286                                                          (1,1)

Meyer MF, Czaplewski H, Braun J, Hellmich B, Schatz H, Klein HH (2005)
Lack of a difference in increased capillary blood cell velocity in the skin over proximal
inter-phalangeal joints between rheumatoid arthritis and osteoarthritis.
Microvasc Res 70:1-6                                                                                                            (3,1)

Meier M, Klein HH, Kramer J, Drenckhan M, Schutt M (2007) Calpain inhibition
 impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling.
J Endocrinol 193:45-51                                                                                                         (2,9)

Meyer MF, Schmidt O, Hellmich B, Schatz H, Klein HH, Braun J (2007) Micro-
vascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry:
relationship to soluble adhesion molecules and extraarticular manifestations. Rheu-
matol Int 28:145-52                                                                                                              (1,5)

Schneider S, Ueberberg S, Korobeynikov A, Schechinger W, Schwanstecher C, Schwanstecher M, Klein HH, Schirrmacher E. (2007) Synthesis and evaluation
of a glibenclamide glucose-conjugate: A potential new lead compound for substituted
glibenclamide derivatives as islet imaging agents. Regul Pept 139 122-127                           (2,2)

Sudhaus S, Fricke B, Schneider S, Stachon A, Klein H, von During M, Hasen-
bring M (2007) The cortisol awakening response in patients with acute and chronic
low back pain: Relations with psychological risk factors of pain chronicity. Schmerz
21:202-211                                                                                                                           (1,5)

Orcy RB, Schroeder S, Martins-Costa SH, Ramos JG, Schechinger W, Klein H,
Brum IS, von Eye Corleta H, Capp E (2008) Signalization of Akt/PKB in the
placenta, skeletal muscle and adipose tissue of preeclampsia patients. Gynecol
Obstet Invest 66(4):231-6

Meyer MF, Lieps D, Schatz H, Klein HH, Pfohl M (2008) Influence of the duration
of type 2 diabetes on early functional and morphological markers of atherosclerosis
compared to the impact of classic cardiovascular risk factors. Exp Clin Endocrinol        
Diabetes 116:298-304                                                                                                            (1,7)

Dietrich JW, Stachon A, Antic B, Klein HH, Hering S (2008) The AQUA-FONTIS
Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal
study for developing standardized diagnostics and classification of non-thyroidal
illness syndrome. BMC Endocr Disord 8:13-22                                                                

Viebahn R, Klein H, Kraemer B, Schenker P (2009) Is Pancreas Transplantation
 Getting Old? Single-center Experience in an Aging Society. Clinical Transplants
 Chapter 12

Sudhaus S, Fricke B, Stachon A, Schneider S, Klein H, Düring M, Hasenbring
M (2009) Salivary cortisol and psychological mechanisms in patients with acute
versus chronic low back pain. Psychoneuroendocrinology 34, 513—522                           (4,2)

Meyer M, Rose CJ, Schatz H, Klein HH (2009) effects of a short term improvement
 in glycemic control on skin microvascular dysfunction in type 1 and type 2 diabetic
subjects. Diabetic Medicine 26 880-886                                                                               (2,9)

Ueberberg S, Meier JJ, Waengler C, Schechinger W, Dietrich JW, Tannapfel A,
Schmitz I, Schirrmacher R, Köller M, Klein HH, Schneider S (2009) Generation
of  novel single-chain antibodies by phage-display technology to direct imaging agents
highly selective to pancreatic {beta}- or {alpha}-cells in vivo. Diabetes 58:2324-34.         (8,5)

Mues C, Zhou J, Manolopoulos KN, Korsten P, Schmoll D, Klotz LO, Bornstein
SR, Klein HH, Barthel A (2009) Regulation of Glucose-6-Phosphatase Gene Expres-
sion by Insulin and Metformin. Horm Metab Res 41:730-5                                                 (2,7)

Meier JJ, Köhler CU, Alkhatib B, Sergi C, Junker T, Klein HH, Schmidt WE,
Fritsch H (2010) β-cell development and turnover during prenatal life in humans.
Eur J Endocrinol 2010 162: 559-568                                                                                  (3,5)

Viebahn R, Klein H, Kraemer B, Schenker P (2009) Is pancreas transplantation
getting old? Single-center experience in an aging society. Clin Transpl. 2009:165-699.     (2,0)

Ueberberg S, Ziegler D, Schechinger W, Dietrich JW, Akinturk S, Klein HH,
Schneider S (2010) In vitro phage display in a rat beta cell line: a simple approach
for the generation of a single-chain antibody targeting a novel beta cell-specific
epitope. Diabetologia 53:1384-1394.                                                                                    (6,6)

Hartleb S, Plöckinger U, Stalla GK, Tuschy U, Weber MM, Pfützner A, Kann PH; German KIMS Board; German KIMS Pharmacogenetics Study Group (2011)
Additive effect of GHRd3 and COLIA1 polymorphisms on the GH-substitution dose in
GH-deficient adults. Pharmacogenomics12:1653-1661                                                     (3.9)

Schneider S, Klein HH (2011) Preserved insulin secretion capacity and graft function
of cryostored encapsulated rat islets. Regul Pept 166:135-138                                            (2,2)

Schneider S, Klein HH (2011) Long-term graft function of cryostored alginate encap-
sulated rat islets. Eur J Med Res 16:396-400.

Ueberberg S, Deutschbein T, Klein HH, Dietrich JW, Akinturk S, Prochnow N, Schirrmacher R, Schneider S (2011) Protection from diabetes development by single-
chain antibody-mediated delivery of a NF-kappa B inhibitor specifically to beta-cells in
vivo. Am J Physiol Endocrinol Metab 301:E83-90                                                              (4,4)

Giebelstein J, Poschmann G, Højlund K, Schechinger W, Dietrich JW, Levin K,
Beck-Nielsen H, Podwojski K,  Stühler K, Meyer HE, Klein HH (2012)  The pro-
teomic signature of insulin resistant human skeletal muscle reveals increased glycoly-
tic and decreased mitochondrial enzymes. Diabetologia 55:1114-1127                               (6,6)

Schöfl C, Franz H, Grussendorf M, Honegger J, Jaursch-Hancke C, Mayr B,
Schopohl J, participants of the German Acromegaly Register. (2013) Long-term
outcome in patients with acromegaly: analysis of 1344 patients from the German
Acromegaly Register. Eur J Endocrinol 168:39-47                                                              (3,5)

Goede SL, Leow MK, Smit JW, Klein HH, Dietrich JW (2014) Hypothalamus-
Pituitary-Thyroid Feedback Control: Implications of Mathematical Modeling
and Consequences for Thyrotropin (TSH) and Free Thyroxine (FT4)
Reference Ranges. Bull Math Biol 76:1270-87

Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A,
Klein HH, Mügge A, Köhrle J, Rijntjes E,Lehmphul I(2015) Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling. Eur Thyroid J  DOI:  10.1159/000381543

Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW (2017) Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming.
Front Endocrinol (Lausanne). 8:163. doi:10.3389/fendo.2017.00163. eCollection 2017   (3,6)

Maasberg S, Pape UF, Fottner C, Goretzki PE, Anlauf M, Hörsch D, Cremer B,
Schulte DM, Quietzsch D, Scheerer F, Pöpperl G, Poeppel TD, Begum N, Grohé C,
Rinke A, Plöckinger U, Wiedenmann B, Arnold R, Neuhaus P, Knapp WH,
Lehnert H, Auernhammer C, Pavel M, von Weikersthal LF, Schmidt B, Klein HH,
Essler M, Neumann JD, Hamann S, Steffens F, Demtröder F, Kröcher A, Zoicas F,
Lahner H, Weber F, Geißler M, Raffel A, Krausch M, Zimmermann P, Lerch MM,
Wirth T, Lang M, Ezziddin S, Lammert F, Bischoff M, Altendorf-Hofmann A,
Müller L, Hoffmeister A, Klose S, Musholt TJ, Post S, Gertler R, Scheuerlein H, Bergmann T, Bisping G, Knauerhase A, Rendenbach B, Groß V, Scheurlen M,
Mönig H, Kudlich T, Grabowski P, Musholt TJ, Watza F, Scheidhauer K, Möbius E (2018) Neuroendocrine Neoplasia within the German NET Registry. Z Gastroenterol
56:1237-1246

Röhling M, Martin T, Wonnemann M, Kragl M, Klein HH, Heinemann L, Martin
S, Kempf K (2019) Determination of postprandial glycemic responses by continuous
glucose monitoring in a real-world setting. Nutrients 11,  doi:10.3390/nu11102305

Müller P, Dietrich JW, Lin T, Bejinariu A, Binnebößel S, Bergen F, Schmidt J,
Müller SK, Chatzitomaris A, Kurt M, Gerguri S, Clasen L, Klein HH, Kelm M,
Makimoto H (2020) Usefulness of Serum Free Thyroxine Concentration to
Predict Ventricular Arrhythmia Risk in Euthyroid Patients With Structural Heart
Disease. Am J Cardiol. 125:1162-1169

Case Reports

Rohe M, Unger H, Henrichs HR, Kerner W, Schier H, Klein HH (1997) Insulin-
bedarf von mehr als 3000I.E./Tag bei einer 29jährigen Patientin mit Dia­­be­tes.
Diabetes und Stoffwechsel 6: 28-33                                                                                    (0,2)

Schütt M, Aries SP, Rosenfeldt M, Peters A, Klein HH (2000) Short term treat-
ment with indinavir fails to reduce the glucose requirement in a patient with malig-
nant insulinoma  Am J Med 108: 524                                                                                  (4,5)

Bätge B, Struck J, Klein HH, Brinckmann J (2000) Schwere Vitamin D-Mangel-Osteomalazie durch Koinzidenz mehrerer Risikofaktoren. Deut Med Wschr 125:
 761-765                                                                                                                               (0,6)

Schütt M, Lorch H, Krüger S, Peters A, Klein HH (2001) Rezidivierende Hypo-
glykämien bei malignem Insulinom: Chemoembolisation als The­rapie­­option.
Med Klin 96: 632-636                                                                                                          (0,5)

Klein J, Ott V, Schütt M, Klein HH (2002) Recurrent hypoglycemic episodes in a
patient with type 2-diabetes under fibrate therapy. J Diabetes Complications 16:
246-248                                                                                                                                (2,1)

von Sengbusch A, Tannapfel A, Klein HH, Hering S (2010) Hepatomegalie und
erhöhte Transaminasen bei einer 24-jährigen Patientin mit Typ 1-Diabetes mellitus.
Internist  51:84-87                                                                                                               (0,3)

Manolopoulos KN, Barthel A, Nicolas V, Klein HH, Hering S (2010) Necroti-
zing fasciitis of the back musculature as a complication of acquired perforating
collagenosis in diabetes mellitus. J Clin Endocrinol Metab 95:11-12                                (6,2)

Dietrich JW, Ehren M, Ruff-Dietrich S, Klein HH (2013) 43-year-old woman
with diabetes and postoperative circulatory collapse. Dtsch Med Wochenschr
138:945

Chatzitomaris A, Scheeler M, Gotzmann M, Köditz R, Schildroth J, Knyhala
KM, Nicolas V, Heyer C, Mügge A, Klein HH, Dietrich JW (2015) Second degree
AV block and severely impaired contractility in cardiac myxedema: a case report.
Thyroid Res. 8:6.                                                                                                                 (1,8)

Chatzitomaris A,Eisenhofer G, Williams TA, Worms O, Nicolas V, Reincke
M , Klein HH Steroid profiling as an additional tool to confirm one-sided hor-
mone overproduction in primary aldosteronism: a case report. Frontiers
Endocrin doi: 10.3389/fendo.2019.00597. eCollection 2019.PMID: 31555214                (3,6)

Reviews

(1989) Insulinrezeptoren und Insulinresistenz. FOCUS MHL 1: 6-8   

Klein HH, Häring HU (1990) Pathogenese des Diabetes mellitus Typ II. Internist
31: 168-179                                                                                                                           (0,3)

Klein, HH (1992) Ätiologie und Pathogenese des Typ-II-Diabetes. Med Welt 43
216-221                                                                                                                               

Beguinot F, Häring H, Kiess W, Klein H, Sesti G, Smith U, Van Obberghen E
(1998) The search for NIDDM genes project: A european community programme
aimed to facilitate the identification of NIDDM genes. Diabetologia 41 (1) 15-16           (6,6)

Kern W, Stange EF, Fehm HL, Klein HH (1999) Glukokortikoid-induzierter Dia-_
betes mellitus bei gastroenterologischen Erkrankungen. Z Gastroenterol 13, Suppl 1:
36-42                                                                                                                                    (1,2)

Schütt M, Meier M, Klein HH (2003) Das HIV-Proteasehemmer-induzierte Insulinresistenzsyndrom. Med Klin  98 271-276                                                                                                                  (0,5)

Ehren M, Klein HH (2004) Hypoglykämien bei der Behandlung von Diabetes:
Patienten und Bezugspersonen für den Ernstfall trainieren. CardioVasc

Klein HH (2004) Aktuelle Kontroversen in der Endokrinologie. MMW-Fortschr.
Med. 9 121

Roggenland D, Schneider S, Klein HH, Kann PH (2006) Endosonographie –
eine zusätzliche Möglichkeit bei der Differenzierung der häufigsten Formen des
Hyperaldosteronismus. Med Klin 101 65-68                                                                       (0,5)

Schneider S, Padzierny G, Klein HH (2006) Orale antidiabetische Therapie. Deut
Med Wschr 131:S264-S268                                                                                              (0,6)

Meier JJ, Schmidt WE, Klein HH (2007) Neue Konzepte in der Behandlung des
Typ 2-Diabetes. Internist 48 798-707                                                                                  (0,3)

Meyer MF, Daigeler A, Lehnhardt M, Steinau HU, Klein HH (2007) Thera-
peutic management of acral manifestations of systemic sclerosis. Med Klin 102:
209-18.                                                                                                                                (0,5)

Schneider S, Manolopoulos K, Klein HH (2007) Das metabolische Syndrom.
Versicherungsmedizin  59:115-119

Thöns M, Müller S, Klein HH (2009) Therapie bei diabetologischen Notfällen.
InFo Diabetologie 3:2-5

Schütt M, Klein HH (2011) Neue Möglichkeiten der Differenzialtherapie des Typ-2-
Diabetes. Internist 52:395-404                                                                                            (0,3)

R,   Kellerer M, Fach E  Gallwitz B,   Hamann A, Joost HG, Klein HH,
Mue­ller-Wieland, Nauck MA, Reuter H-M, Schreiber S, Siegel E,  Matthaei S
(2013) Praxis­empfehlungen der DDG und DGIM für die Behandlung des Typ 2-Diabetes (aktualisiert) Diabetologie und Stoffwechsel S146-S151                                                               (0,5)

R,   Kellerer M, Fach E  Gallwitz B,   Hamann A, Joost HG, Klein HH,
Mue­ller-Wieland, Nauck MA, Reuter H-M, Schreiber S, Siegel E,  Matthaei S
(2014) Praxis­empfehlungen der DDG und DGIM für die Behandlung des Typ 2-Diabetes (aktualisiert) Diabetologie und Stoffwechsel S138-S148                                                               (0,5)

Pfeiffer AF, Klein HH (2014) The treatment of type 2 diabetes. Dtsch Arztebl
Int 111: 69-81                                                                                                                      (3.7)

R,   Kellerer M,  Fach E  Gallwitz B,   Hamann A, Joost HG, Klein HH,
Mue­ller-Wieland, Nauck MA, Reuter H-M, Schreiber S, Siegel E,  Matthaei S
(2015) Praxis­empfehlungen der DDG und DGIM für die Behandlung des Typ 2-Diabetes (aktualisiert) Diabetologie und Stoffwechsel S140-S151                                                               (0,5)

Köditz R, Klein HH (2016) Osteoporose-Prophylaxe: Mehr Kalzium beeinflusst   Knochendichte und Frakturrisiko kaum. Dtsch Med Wochenschr  141:10                                              (0,5)

Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH,
Midgley JEM and Hoermann R (2016) Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research.
Front. Endocrinol. 7:57

R,   Kellerer M,  Fach E  Gallwitz B,   Hamann A, Joost HG, Klein HH,
Mue­ller-Wieland, Nauck MA, Reuter H-M, Schreiber S, Siegel E (2016) Therapie
des Typ 2-Diabetes.  Diabetologie und Stoffwechsel 11(S 02): S117-S129           (0,9)

Pfeiffer A. F. H., Gebauer S, Rubin D, Schulze M., Buchholz G., Klein H., Li-
lienfeld-Toal,Reinert G,, Simon M, Müssig KSkurk T, Hauner H, Tombek A,
Müller M. J,Fischer S, Weickert M. O, Hoffmann D (2016)  Ernährungsem-
pfehlungen zur Behandlung des Diabetes mellitus – Empfehlungen zur Proteinzufuhr Diabetologie und Stoffwechsel  11:272-282                                                                                                   (0,9)

Landgraf, R, Kellerer M, Fach, EM, Gallwitz B, Hamann A, Joost H-G, Klein
H, Müller-Wieland D, Nauck MA, Reuter H-M, Schreiber S, Siegel E (2017)
Therapie des Typ 2-Diabetes. Diabetologie und Stoffwechsel 12 (S 02):S141-
S156

Haak T, Gölz S, Fritsche A, Füchtenbusch M, Siegmund T, Schnellbächer E,
Klein HH, Uebel T, Droßel D (2018) Therapie des Typ 1-Diabetes – Kurz-
fassung der S3-Leitlinie (AWMF 057-13, 2. Auflage) Stand 30. Juni 2018.
Diabetologie und Stoffwechsel 13 (S 02) S120-S130                                             (0,9)

Landgraf R, Kellerer M, Aberle J, Fach EM, Gallwitz B, Hamann A, Joost
HG, Klein HH, Müller Wieland D, Nauck MA, Reuter HM, Schreiber S,
Siegel E (2018) Therapie des Typ 2-Diabetes. Diabetologie und
Stoffwechsel 13(S 02): S90-S96 S144-S165                                                                  (0,9)

Ehren M, Klein HH (2019) Insulintherapie-neue Insulinanaloga. Internist 60:
887-894. doi: 10.1007/s00108-019-0652-1                                                                          (0,4)

Landgraf R, Kellerer M, Aberle J, Fach EM, Gallwitz, B, Hamann A,Joost
HG, Klein HH,Müller-Wieland D, Nauck MA, Reuter HM, Schreiber S,
Siegel E (2019)  Therapie des Typ 2-Diabetes.  Diabetologe (2019) Diabetologie
14 (Suppl 2): S167–S187

Worms O. Klein HH (2019) Unerwünschte Wirkung der oralen Antidiabetika.

Intern Praxis, 61:346-351

Landgraf R, Aberle J, Birkenfeld AL; Gallwitz B, Kellerer M, Klein HH,
Müller-Wieland D, Nauck MA, Reuter H-M, Siegel E (2020) Therapie des
Typ 2-Diabetes. Diabetologie 15 (Supp 1) S65-S92

Haak T,Gölz S,Fritsche A,Füchtenbusch M, Siegmund T, Schnellbä-
cher E, Klein HH,  Uebel T, Droßel D (2020) Therapie des Typ-1-Diabetes.
Kurzfassung der S3-Leitlinie (AWMF-Registernummer: 057-013; 2. Auflage)
Diabetologie 2020; (Suppl 1): S40–S50

Articles in books

Klein HH, Schneider S (2005-2006) Themengebiete Endokrinologie und
Stoffwechsel. In: Brockhaus Enzyklopädie, 21. Aufl, Bibliographisches Institut
& F. A. Brockhaus AG, Mannheim, ISBN: 978-3-577-90001-0

Klein HH (2009) Typ 2-Diabetes: Medizinische und sozioökonomische
Aspekte einer durch Wohlstand ausgelösten Epidemie. In: Gesundheit:
Geisteswissenschaftliche und Medizinische Aspekte, Hg: Geerlings W,
Mügge A, LIT Verlag Dr W Hopf, Berlin, ISBN 978-3-643-10026-9

Ehren M, Burchard D, Müller-Wieland D, Klein HH (2011) Klinische Dia-
betologie: Operationen. In: Diabetologie in Klinik und Praxis 6. Auflage, Hg:
Häring HU et al., Thieme, ISBN 978-3-13-512806-1, 326-330

Gallwitz B, Joost HG, Klein H, Matthaei S (2011) Insulinotrope orale Antidia-
betika und inkretinbasierte Therapieformen. In: Diabetologie in Klinik und Pra-
xis 6. Auflage, Hg: Häring HU et al., Thieme, ISBN 978-3-13-512806-1, 167-180  

Klein HH (2013) Diabetes und andere endokrine Erkrankungen. In; Kursbuch
Klinische Diabetologie, Hg. Nauck MA und Meier JJ, Kirchheim, ISBN 978-
3874094351, 286-288

Klein HH (2013) Leitlinien der Deutschen Diabetes Gesellschaft. In: Diabetologie
Kompakt, Hg. Schatz H und Pfeiffer AFH, Thieme, ISBN 978-3-642-41357-5, 34-36

Klein HH (2021)  Orale Medikamente mit Einfluss auf die Insulinsensitivität. In
Diabetologie in Klinik und Praxis, Hg Häring HU, Gallwitz B, Müller-Wieland D,
Badenhoop K, Meier JJ, Usadel K-H, Mehnert H, Thieme, ISBN 978-313-242892-8,
 203-206

Editor

Sonderheft Diabetes

Leitlinien

Pfeiffer A. F. H., Gebauer S, Rubin D, Schulze M., Buchholz G., Klein H., Lilien-
feld-Toal,Reinert G,, Simon M, Müssig KSkurk T, Hauner H, Tombek A, Müller
M. J,Fischer S, Weickert M. O, Hoffmann D  Ernährungsempfehlungen zur Behand-
lung des Diabetes mellitus – Empfehlungen zur Proteinzufur (2015) S3-Leitlinie
AWMF 057-025

Haak T, Gölz S, Fritsche A, Füchtenbusch M, Siegmund T, Schnellbächer E,
Klein HH, Spies C, Uebel T, Droßel D, Wiegand S Therapie des Typ 1-Diabetes
S3-Leitlinie AWMF 057-13, 2. Auflage

 Agostini H, Barkhausen J, Blödt S, Brockcamp C, Debus S, Dissemond J, Einhard
N, Enax-Krumova E, Fründ A, Ghods M, Grundke S, Härder M, Hübner P, Joisten
C, Klein HH, Kopp I, Krirschner-Hermanns R, Krüger M, Kruse J, Landgraf R, Langhorst J, Lawall H, Layer P, Lehmann HC, Marx N, Mayer-Hasselmann A,
Mertens N, Müller UA, Nothacker M, Petrak F, Pfersich T, Prien P, Rubin D,
Rueb M, Rümenapf G, Schäfer C, Schmidt M, Schöbel C, Schöning D, Schorr S,
Schüler S, Uebel T, Vader I, Westheide J, Zeyfang A  Nationale VersorgungsLeitlinie (NVL) Typ-2-Diabetes – Teilpublikation, 2. Auflage, Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaf-
tlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie
Typ-2 -Diabetes – Teilpublikation der Langfassung, 2. Auflage. Version 1. 2021
[cited: YYYY-MM-DD]. DOI: 10.6101/AZQ/000475. www.leitlinien.de/diabetes